Green tree frogs use a variety of defence mechanisms to protect themselves from predators, combining physical, chemical, and behavioural strategies:
- Camouflage: Their green coloration allows them to blend in with leaves and vegetation, making it difficult for predators to spot them. By remaining motionless during the day and hiding in foliage, tree hollows, or crevices, they further avoid detection.
- Climbing Ability: Thanks to their sticky toe pads, green tree frogs can quickly escape ground-based threats by climbing trees or vegetation, moving to locations that many predators cannot easily reach.
- Skin Secretions: When threatened, green tree frogs can secrete a noxious, sometimes sticky substance from their skin. This secretion can be irritating or distasteful to predators, deterring attacks and sometimes causing the predator to release the frog.
- Behavioral Tactics: Like many frogs, they may jump away suddenly or leap into water or higher branches to escape. Some frogs puff up their bodies to appear larger and more intimidating, or even play dead to avoid attracting attention.
- Colour Change: Green tree frogs can change their skin color to better match their environment, enhancing their camouflage and making them less visible to predators.

These combined adaptations help green tree frogs survive in environments with numerous predators, from snakes and birds to mammals and larger frogs. Their reliance on camouflage, rapid escape, and chemical defenses are especially important for avoiding predation in the wild.